Yes. Pearl Street Warehouse is accessible by metro (a 5-minute walk from Waterfront Metro Stop (Green Line) and a 10-minute walk from L’Enfant Plaza Metro Stop (Green, Yellow, Orange, Blue, and Silver lines).
You can walk from downtown DC — it takes 10-20 minutes from the Mall. You can take a water taxi from Georgetown, Old Town Alexandria, The Yards, and National Harbor, a free Wharf Jitney between Hains Point and East Potomac Park, and a shuttle from the National Mall, L’Enfant Plaza and more.